摘要Background:The 9-hole peg test (9-HPT) and 10-meter walk test (10-MWT) are commonly used to test finger motor function and walking ability.The aim of this present study was to investigate the efficacy of these tests for evaluating functional loss in Chinese Charcot-Marie-Tooth (CMT) disease.Methods:Thirty-four Chinese CMT patients (CMT group) from August 2015 to December 2016 were evaluated with 9-HPT,10-MWT,CMT disease examination score,overall neuropathy limitation scale (ONLS),functional disability score,and Berg Balance Scale (BBS).Thirty-five age-and gender-matched healthy controls (control group) were also included in the study.Student's nonpaired or paired t-test were performed to compare data between two independent or related groups,respectively.The Pearson test was used to examine the correlations between recorded parameters.Results:The mean 9-HPT completion time in the dominant hand of CMT patients was significantly slower than that in the healthy controls (29.60 ± 11.89 s vs.19.58 ± 3.45 s;t =-4.728,P ＜ 0.001).Women with CMT completed the 9-HPT significantly faster than men with CMT (dominant hand:24.74 ± 7.93 s vs.33.01 ± 13.14 s,t =2.097,P =0.044).The gait speed of the average self-selected velocity and the average fast-velocity assessed using 10-MWT for CMT patients were significantly slower than those in the control group (1.03 ± 0.18 m/s vs.1.44 ± 0.17 m/s,t =9.333,P ＜ 0.001;1.31 ± 0.30 m/s vs.1.91 ± 0.25 m/s,t =8.853,P ＜ 0.00 1,respectively).There was no difference in gait speed between men and women.Both 9-HPT and 10-MWT were significantly correlated with the ONLS,functional disability score,and BBS (P ＜ 0.05 for all).Conclusion:The 9-HPT and 10-MWT might be useful for functional assessment in Chinese patients with CMT.