摘要Atrial fibrillation (AF) is the most common type of arrhythmia,which is reported to increase the incidence of stroke by five to seven folds,leading to the irregular ventricular rhythm and adversely impacted life quality,and the mortality could be increased as well by AF per se.[1]Shen Song Yang Xin (SSYX) capsule is a novel traditional Chinese medicine composed of more than a dozen Chinese medicine herbs with significant antiarrhythmic effect.In the current study,the effect of SSYX capsule has been tested in an animal study and it was also indicated by randomized double-blinded,positive drug-controlled clinical trials.[2]However,the working mechanism of SSYX capsule as antiarrhythmic drug is not completely clear yet.[3,4] This study tried to investigate the effect of SSYX capsule on the myocardial electrophysiology of acute AF dog model.