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Corticosteroid?induced Osteonecrosis of the Femoral Head:Detection, Diagnosis, and Treatment in Earlier Stages

摘要Objective: This review aimed to provide a current recommendation to multidisciplinary physicians for early detection, diagnosis, and treatment of corticosteroid?induced osteonecrosis of the femoral head (ONFH) based on a comprehensive analysis of the clinical literature. Data Sources: For the purpose of collecting potentially eligible articles, we searched for articles in the PubMed, Cochrane Library, Embase, and CNKI databases up to February 2017, using the following key words: "corticosteroid", "osteonecrosis of the femoral head","risk factors", "diagnosis", "prognosis", and "treatment". Study Selection: Articles on relationships between corticosteroid and ONFH were selected for this review. Articles on the diagnosis, prognosis, and intervention of earlier?stage ONFH were also reviewed. Results: The incidence of corticosteroid?induced ONFH was associated with high doses of corticosteroids, and underlying diseases in certain predisposed individuals mainly occurred in the first 3 months of corticosteroid prescription. The enhanced awareness and minimized exposure to the established risk factors and earlier definitive diagnosis are essential for the success of joint preservation. When following up patients with ONFH, treatment should be started if necessary. Surgical treatment yielded better results than conservative therapy in earlier?stage ONFH. The ideal purpose of earlier intervention and treatment is permanent preservation of the femoral head without physical restrictions in daily living. Conclusions: Clinicians should enhance their precaution awareness of corticosteroid?induced ONFH. For high?risk patients, regular follow?up is very important in the 1st year after high?dose prescription of corticosteroids. Patients with suspected ONFH should be referred to orthopedists for diagnosis and treatment in its earlier stage to preserve the joint.

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作者单位 Peking Union Medical Col ege, China?Japan Friendship Institute of Clinical Medicine, Beijing 100029, China [1] Department of Orthopaedic Surgery, Centre for Osteonecrosis and Joint Preserving and Reconstruction, China?Japan Friendship Hospital, Beijing 100029, China [2]
栏目名称 Review Articles
DOI 10.4103/0366?6999.217094
发布时间 2017-12-06
基金项目
This study was supported by grants from the National Natural Science Foundation of China China?Japan Friendship Hospital Youth Science and Technology Excellence Project
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中华医学杂志(英文版)

中华医学杂志(英文版)

2017年21期

2601-2607页

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