A Rarely Concerned Magnetic Resonance Image Sign of Spinal Nerve Root Hypertrophy in Type 1A Charcot-Marie-Tooth Disease

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摘要To the Editor:Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous inherited neuropathy,with Type 1 A being the most common.CMT 1A is characterized by progressive weakness and atrophy of the distal limb muscles beginning in the peroneal group,mild distal sensory loss,diminished tendon reflexes,and slow nerve conduction velocity.[1] Spinal nerve root hypertrophy is a distinct sign of CMT 1A.[2] This sign can be detected on magnetic resonance images (MRI),but it is often overlooked.Instead,diagnosis of this disease is often made basing on biopsy and genetic testing.

作者单位 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China ^[1] National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing 100053, China;Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China ^[2] Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China ^[3] Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China ^[4] Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing 100053, China ^[5]

栏目名称

Correspondence

DOI 10.4103/0366-6999.218017

发布时间 2018-01-03

基金项目

grants from the National Natural Science Foundation of China（81470074 and 81401040）； Clinical Fund from Beijing Municipal Science and Technology Committee（Z141107002514117）； Beijing Municipal Government Fund（PXM2017_026283_000002）

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