Application of the Next-Generation Sequencing Technology to Reveal Mechanism of Small Cell Lung Cancer Transformation from Adenocarcinoma
摘要To the Editor:Small cell lung cancer (SCLC) transformation is one of the most common mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in non-SCLC (NSCLC).However,whether such transformation is one from NSCLC to SCLC or the coexistence of both remains controversial.[1] In this study,we performed next-generation sequencing (NGS) with a panel of 168 tumor genes for consecutive repeat biopsy tissue samples of a lung adenocarcinoma patient harboring EGFR exon 19 deletion (ex19del).
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