Neutrophil Extracellular Traps in Autoimmune Diseases

二维码有效期 120s

摘要INTRODUCTION In 2004,NETosis was first reported as an important step to kill bacteria by neutrophils.During the process of NETosis,neutrophil extracellular traps (NETs) that contain large web-like structures of decondensed chromatin decorated with histones and intracellular components,including neutrophil elastase (NE),myeloperoxidase (MPO),high mobility group protein B1 (HMGB1),and proteinase 3 (PR3),are extruded into the extracellular space.[1] The structures of NETs enable the neutrophil to potently catch and kill pathogens at the site of inflammation.Furthermore,increasing studies have identified the presence of NETs in autoimmune diseases.

作者单位 Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510630, China ;Institute of Clinical Immunology, Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong 510630, China ^[1] Southern Medical University, Guangzhou, Guangdong 510630, China ^[2]

关键词 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Autoimmunity Neutrophil Extracellular Traps Rheumatoid Arthritis Systemic Lupus Erythematosus

栏目名称

Editorial

DOI 10.4103/0366-6999.235122

发布时间 2018-08-13

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