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Severe Lymphopenia and Related T-cell Immunity in an Avian Influenza A (H7N9)-Infected Patient

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摘要To the Editor:Following H7N9 infection,the host lymphocyte immunity plays an antiviml role.[1] Furthermore,low frequencies of T-cells correlate with disease severity.[2] Herein,we present a H7N9-infected patient with life-threatening lymphopenia (only 0.06 × 109/L in the peripheral blood),which we have barely ever seen before.We also measured the proportions of T-cell subpopulations in the blood and bronchoalveolar lavage fluid (BALF).

作者单位 Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China;Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China;National Clinical Research Center for Respiratory Diseases, Beijing 100029, China;Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China ^[1] Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China;Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China;National Clinical Research Center for Respiratory Diseases, Beijing 100029, China ^[2]

栏目名称

Correspondence

DOI 10.4103/0366-6999.245268

发布时间 2018-12-14（万方平台首次上网日期，不代表论文的发表时间）

基金项目

This study was supported by the grants from the National Natural Science Foundation of China（.1470270 and 81401629）； the National Key Research and Development Program of China（2016YFC1304300）； the Capital Clinical Features Applied Research and Achievement Promotion Project of Beijing,China（Z161100000516116）

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