Identification of Transcription Regulatory Relationships in Diabetic Nephropathy

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摘要To the Editor: Diabetic nephropathy (DN) is the leading cause of chronic renal diseases and accounts for almost 50％ of all end?stage renal diseases worldwide. The prevalence of DN increased significantly after 2010 in China.[1,2] DN is clinically characterized by proteinuria and morphological and ultrastructural changes in the kidney. The pathogenesis of DN is multifactorial and extremely complex, including hyperglycemia, transforming growth factor (TGF)?β1, angiotensin II, DNA methylation, chromatin histone modification, microRNAs, and long noncoding RNAs.

作者单位 National Clinical Research Center of Kidney Diseases, Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210016, China ^[1]

栏目名称

Correspondence

DOI 10.4103/0366-6999.246063

发布时间 2018-12-20

基金项目

The work was supported by grants from the National Key Research and Development Program of China（2016YFC0904103）； the National Natural Science Foundation of China（81500556, 81500548, and 81500547）； the Innovation Capability Development Project of Jiangsu Province（BM2015004）

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