Diagnostic Value of Sensitive Biomarkers for Early Kidney Damage in Diabetic Patients with Normoalbuminuria

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摘要To the Editor: Diabetic kidney disease (DKD) is the most common cause of end?stage renal disease (ESRD); however, the onset of DKD is difficult to detect.[1] When persistent microalbuminuria becomes detectable, DKD has already progressed to the third disease stage, and finding biomarkers that are more sensitive than microalbuminuria is therefore necessary to indicate kidney damage at an earlier stage of DKD.[2] Both glomerular and tubulointerstitial damages have been repeatedly demonstrated to be important factors in the pathophysiology of DKD.[3] Therefore, we investigated the expression levels of six markers closely related to the glomerulus and renal tubule.

作者单位 Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China ^[1] Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology in Zhengzhou University, Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, Henan 450052, China ^[2]

栏目名称

Correspondence

DOI 10.4103/0366-6999.246080

发布时间 2018-12-20

基金项目

This study was supported by the grants from the National Key R&D Program of China（2016YFC1305500 and 2016YFC1305404）； the National Natural Science Foundation of China（61471399, 61671479, and 81670663）； the Joint Funds of National Natural Science Foundation of China and Henan Province（U1604284）； the Special Research Project on Health Care of the Chinese People's Liberation Army（15BJZ35）

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