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Neurological Abnormality Could be the First and Only Symptom of Familial Hemophagocytic Lymphohistiocytosis:Report of Two Families

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摘要To the Editor: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease which impacts many parts of the body including the digestive, circulatory, and respiratory systems. The central nervous system (CNS) can also be affected, particularly in patients with familial HLH-2 (FHL-2), responsible for approximately 20% of all FHL.

作者单位 Beijing Key Laboratory of Pediatric Hematology Oncology;National Key Discipline of Pediatrics (Capital Medical University);Key Laboratory of Major Diseases in Children, Ministry of Education;Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China ^[1] Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China ^[2] Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China ^[3]

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Correspondence

DOI 10.4103/0366-6999.247206

发布时间 2019-01-03（万方平台首次上网日期，不代表论文的发表时间）

基金项目

the grants from the National Science and Technology Key Projects（2017ZX09304029004）； Beijing Municipal Science and Technology Commission（Z171100001017050）； National Natural Science Foundation of China（81700186, 81800189）； Scientific Research Common Program of Beijing Municipal Commission of Education No.KM201710025019)（GPY201713）； Talent Training Project-Fostering Fund of National Natural Science Foundation of Beijing Children's Hospital, Capital Medical University（XTZD20180202）； The Special Fund of The Pediatric Medical Coordinated Development Center of Beijing Municipal Administration

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