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White matter connection's damage, not cortical activation, leading to language dysfunction of mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes

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摘要Mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS) is a metabolic disorder characterized by hyperlactic acidemia and stroke-like symptoms.[1] The clinical symptoms of MELAS are complex and diverse,with an incidence of 39.47％ of aphasia.[2] MELAS is often considered to be gray matter damage,little studies investigated its white matter changes.

作者单位 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University;China National Clinical Research Center for Neurological Diseases;Center of Stroke, Beijing Institute for Brain Disorders;Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease;Beijing Key Laboratory of Central Nervous System Injury, Beijing 100070, China ^[1] Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China ^[2] Department of Neurology, Beijing Tiantan Hospital, Capital Medical University;China National Clinical Research Center for Neurological Diseases;Center of Stroke, Beijing Institute for Brain Disorders;Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease;Beijing Key Laboratory of Central Nervous System Injury, Beijing 100070, China;Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China ^[3]

栏目名称

Clinical Observation

DOI 10.1097/CM9.0000000000000105

发布时间 2019-04-16（万方平台首次上网日期，不代表论文的发表时间）

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