Hailey-Hailey disease with lichenoid lesions around the anus

二维码有效期 120s

摘要To the Editor:Hailey-Hailey disease (HHD),first discovered by the brothers Howard and Hugh Hailey,[1] is a genodermatosis at intertriginous sites.Mutation of ATP2C1 on chromosome 3q21-2 coding a calciumdependent ATPase gives rise to calcium dysfunction within keratinocytes,resulting in acantholysis due to a signal transduction disorder.[2] It has been suggested that this gene mutation combined with irritation such as frequent friction,cold,and ultraviolet exposure leads to the development of HHD.[3]

作者单位 Department of Dermatology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China ^[1]

栏目名称

Correspondence

DOI 10.1097/CM9.0000000000000097

发布时间 2019-04-29

基金项目

This study was supported by National Natural Science Foundation of China（81371731）； Milstein Medical Asian American Partnership foundation（2017,dermatology）； Education Reform Projects of Peking Union Medical College（2016zlgc0106）

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