摘要To the Editor:Overactive bladder (OAB) is a common clinical manifestation of voiding dysfunction.The incidence of OAB among people over 18 years old is 5.9％,and is known to increase with age up to an incidence of 11.3 ％ in people over 40 years old in China.OAB seriously affects the quality of life,causing great inconvenience to patients' work and home life that can result in a variety of physiologic,psychologic,and social problems.The diagnosis of OAB depends mainly on the patient's subjective clinical symptoms,as well as auxiliary examination including invasive urodynamic examination,a urination diary,and a symptom questionnaire,which can lack objectivity and accuracy.Thus,in recent years,there has been interest in identifying biomarkers of OAB.Potential biomarkers of OAB identified to date include the nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).