摘要To the Editor:Endometriosis refers to the endometrial tissue (interstitial substance and gland) with growth function occurring in the uterine lining of uterine cavity and the places outside myometrium.It often leads to pain,infertility,nodules or masses and other symptoms and signs,and thus,brings a heavy burden on individuals and society.Traditional blood reflux theory,immune theory,inflammatory theory,hormone theory,etc.,cannot fully elucidate the pathogenesis of endometriosis.Recent studies have shown that there is some specificity in eutopic endometria of patients with endometriosis themselves,making it possible that endometrial fragments adhere,invade,and grow outside of the uterine cavity.[1,2] Eutopic endometria may be one of the key factors in the occurrence of endometriosis.This study intends to use the whole exome sequencing (WES) and gene chip sequencing technology to explore the role of eutopic endometria of patients with ovarian endometriosis (OEM) in the pathogenesis of endometriosis.