摘要To the editor:Bladder cancer exhibits significant sex differences in incidence,diagnosis,management,and survival.[1] The incidence of bladder cancer in males is approximately three-fold higher than that in females.Although women are generally less likely to develop bladder cancer than men,once females acquire this disease,the prognosis is less favorable.However,the molecular basis of these sex disparities in bladder cancer remains poorly understood.Studies suggest that bladder cancer has more somatic DNA alterations than almost any other cancer types,but the specific differences between males and females remain unknown.[2] To determine the genomic mutations of sex discrepancies in bladder cancer,we investigated sexspecific somatic DNA alterations by analyzing highthroughput data obtained from The Cancer Genome Atlas (TCGA),including 304 Caucasian samples of muscleinvasive bladder carcinoma (224 males and 80 females).