Efferocytosis: A new therapeutic target for stroke

二维码有效期 120s

摘要Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells, which is essential for maintaining tissue homeostasis both in physiological and pathological conditions. Numerous studies have demonstrated that efferocytosis can prevent secondary necrosis and proinflammatory factor release, leading to the resolution of inflammation and tissue immunological tolerance in numerous diseases such as stroke. Stroke is a leading cause of death and morbidity for adults worldwide. Persistent inflammation triggered by the dead cells or cell debris is a major contributor to post-stroke brain damage. Effective efferocytosis might be an efficient strategy to minimize inflammation and restore brain homeostasis for neuronal regeneration and function recovery. In this review, we will discuss the phagocytes in the brain, the molecular mechanisms underlying efferocytosis, the role of efferocytosis in inflammation resolution, and the potential therapeutic applications targeting efferocytosis in stroke.

abstractsEfferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells, which is essential for maintaining tissue homeostasis both in physiological and pathological conditions. Numerous studies have demonstrated that efferocytosis can prevent secondary necrosis and proinflammatory factor release, leading to the resolution of inflammation and tissue immunological tolerance in numerous diseases such as stroke. Stroke is a leading cause of death and morbidity for adults worldwide. Persistent inflammation triggered by the dead cells or cell debris is a major contributor to post-stroke brain damage. Effective efferocytosis might be an efficient strategy to minimize inflammation and restore brain homeostasis for neuronal regeneration and function recovery. In this review, we will discuss the phagocytes in the brain, the molecular mechanisms underlying efferocytosis, the role of efferocytosis in inflammation resolution, and the potential therapeutic applications targeting efferocytosis in stroke.

作者 Gao Li ^[1] Manaenko Anatol ^[2] Zeng Feng ^[3] Li Jingchen ^[4] Liu Lele ^[4] Xie Ruichuan ^[4] Zhang Xiaohua ^[1] Zhang John H. ^[5] Mei Qiyong ^[3] Tang Jiping ^[5] Hu Qin ^[1] 学术成果认领

作者单位 Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China ^[1] Clinical Neuroanatomy, Department of Neurology, School of Medicine, Ulm University, Ulm 89081, Germany ^[2] Department of Neurosurgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China ^[3] Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China ^[4] Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92354, USA ^[5]

关键词 Stroke Efferocytosis Inflammation resolution Apoptotic cell clearance Stroke Efferocytosis Inflammation resolution Apoptotic cell clearance

栏目名称 Review Article

DOI 10.1097/CM9.0000000000003363

发布时间 2025-02-25

基金项目

National Natural Science Foundation of China Natural Science Foundation of Shanghai Research Program of Science and Technology Commission of Shanghai Municipality Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation