摘要目的 探讨声触诊组织量化(VTQ)技术对进展期胃癌Lauren分型的评估价值.方法 对术前胃镜活检术后经病理证实的41例胃癌患者术前行VTQ检查,测量各病灶组织的剪切波速度(SWV),术后对胃癌标本行HE染色及AB-PAS黏液染色,并据此进行Lauren分型.比较胃癌不同Lauren亚型间SWV的差异.结果 41例胃癌标本组织学诊断为弥漫型者26例,肠型者15例.弥漫型胃癌SWV明显高于肠型胃癌,差异有统计学意义[(1.72±0.83) m/s对(1.05±0.66)m/s,t=2.819,P=0.008].由ROC曲线可知,当SWV截值=1.045m/s(曲线下最大面积=0.795)时,其预测弥漫型胃癌的敏感性和特异性分别为80.8％和73.3％.结论 利用VTQ检查可以在术前初步判断进展期胃癌的Lauren分型.

abstractsObjective To explore the value of virtual touch tissue quantification (VTQ) in evaluating Lauren classification of advanced gastric carcinoma.Methods Forty-one patients with gastric cancer proved by endoscopic biopsy performed preoperative VTQ examination,and the findings were compared with postoperative pathologic results via hematoxylin -eosin and Alcian Blue-Periodic Acid Schiff (AB-PAS) staining.Results In 41 patients,26 cases were diagnosed as diffuse type and 15 cases as intestinal type by pathology after operation.The shear wave velocity(SWV) of diffuse type was higher than that of intestinal type [(1.72± 0.83)m/s vs (1.05± 0.66)m/s,t =2.819,P=0.008] measured by virtual touch tissue quantification (VTQ).According to the area under the ROC curve,the cut- off value of SWV in gastric cancer tissues for assessing the diffuse type was 1.045 m/s with a sensitivity of 80.8％ and specificity of 73.3 ％ respectively.Conclusions VTQ could be considered as a promising method to distinguish the Lauren classification in patients with advanced gastric carcinoma.