摘要目的:基于全球疾病负担（GBD）数据库，分析1990—2021年我国妊娠期高血压疾病（HDP）的发生率及伤残调整寿命年（DALY）的变化趋势及国际差异。方法:数据来源于GBD数据库，涵盖全球的HDP发生率和DALY数据。采用描述性统计，比较我国与不同发达国家的疾病负担差异，分析育龄期妇女在不同年龄段（每5岁一组）的疾病负担特征；采用联接点回归模型识别趋势变化点；通过年龄-时期-队列模型，分析年龄、时期和出生队列的独立影响。结果:（1）1990—2021年间，我国HDP在育龄期妇女中的发生率总体呈下降趋势，从1990年的387.18/10万下降到2021年的216.35/10万。与全球的发病率（1990年：1 167.28/10万；2021年：923.48/10万）比较，我国HDP的发生率较低，但仍高于部分发达国家。（2）联接点回归模型分析显示，不同年龄段HDP的发生率呈先降低再升高最后趋于平缓的趋势，其中最低点的联接点是2005年。DALY在各个年龄段均呈持续下降趋势，其中，15~39岁各个年龄段的孕产妇DALY的下降均较为明显。（3）年龄-时期-队列效应模型显示，20~24岁育龄期妇女的HDP发生率及DALY均达峰值。结论:我国HDP疾病负担持续减轻，疾病防控成效显著，但发生率仍高于部分发达国家。建议针对不同风险群体制定个体化干预措施以进一步降低疾病负担。

abstractsObjective:To analyze the changing trends and international differences in the incidence and disability-adjusted life years (DALY) of hypertensive disorders in pregnancy (HDP) in China from 1990 to 2021 based on the Global Burden of Disease (GBD) database.Methods:The data were derived from the GBD database, covering the incidence and DALY data of HDP in countries or regions around the world. Descriptive statistics were used to compare the differences in disease burden between China and different regions of Europe, America and other developed countries, and to analyze the disease burden characteristics of women of childbearing age in different age groups (every 5 years). The Joinpoint regression model was used to identify trend change points. The age-period-cohort model was used to analyze the independent effects of age, period and birth cohort.Results:(1) From 1990 to 2021, the incidence of HDP in China showed an overall downward trend, from 387.18/100 000 in 1990 to 216.35/100 000 in 2021. Compared with the global incidence rate (1990: 1 167.28/100 000; 2021: 923.48/100 000), the incidence rate of HDP in China was relatively low, but it was still higher than that in some developed countries. (2) The analysis of the Joinpoint regression model showed that the incidence rate of HDP in different age groups first decreased, then increased, and finally leveled off. The connection point with the lowest point was in 2005. DALY showed a continuous downward trend in all age groups. Among them, the decline in maternal DALY of pregnant women in all age groups from 15 to 39 years old was more obvious. (3) The age-period-cohort effect model showed that the incidence rate and DALY of HDP in women of childbearing age aged 20 to 24 years reached their peak.Conclusions:The burden of HDP in China continues to decrease, and the disease prevention and control has achieved remarkable results, but the incidence rate is still higher than that in some developed countries. It is suggested that personalized interventions should be developed for different risk groups to further reduce the burden of disease.