摘要目的 观察依达拉奉联合高压氧(HBO)治疗83例急性脑梗死患者的效果.方法 166例急性脑梗死患者分为依达拉奉治疗组(药物组)和依达拉奉联合HBO治疗组(HBO综合组),每组83例.药物组每天2次静脉滴注依达拉奉30 mg,HBO综合组除用依达拉奉治疗外,每天行HBO治疗1次,压力0.22 MPa,时间80 min,共治疗21 d,对2组患者住院3周后进行神经功能评分,以观察疗效,检测凝血酶原时间(PT)和纤维蛋白原(FIB)水平.结果 治疗第2周、第3周HBO综合组神经功能评分和疗效显著高于治疗前和药物组(P<0.05或0.01);HBO综合组PT的增高幅度大于药物组(P<0.05),血浆FIB水平则显著低于药物组(P<0.05或0.01).结论 依达拉奉联合HBO治疗的效果优于单纯用药,且HBO综合治疗可使PT增高和FIB水平显著降低.

abstractsObjective To investigate therapeutic effect of Edaravone combined with HBO on acute cerebral infarction in 83 cases. Methods One hundred and sixty - six cases of acute cerebral infarction were equally divided into two groups, the Edaravone treatment group (the simple medication group) (n = 83) and the Edaravone combined with HBO treatment group (the medication plus HBO group) (n = 83). The simple medication group was administered with an injection of 30 mg Edaravone twice a day, and the medication plus HBO group was treated by Edaravone combined with HBO. Neural function was compared and analyzed between the groups following 3 weeks of treatment to assess therapeutic effects, to monitor prothrombin time (PT), and the level of fibronogen. Results After the second and third week of the treatment, neural functional scores and therapeutic efficacy for the medication plus HBO group were obviously better than those of the simple medication group (P < 0. 05 or 0. 01). The level of PT for the medication plus HBO group was obviously greater (P <0. 05), while the level of serum FIB was significantly lower than that of the simple medication group (P < 0. 05 or 0. 01). Conclusions The therapeutic effect of Edaravone combined with HBO was obviously better than that of the simple medication group. In addition, Edaravone combined with HBO could obviously increase the levels of PT and decrease the levels of FIB.