摘要目的 研究高压氧对左心室射血分数(LVEF)正常的心力衰竭患者血浆中一氧化氮(NO)、降钙素基因相关肽(CGRP)、内皮素(ET)和抵抗素的影响。方法 将67例左心室射血分数正常的心力衰竭患者分为高压氧组（33例）与对照组（34例）。治疗前后分别检测血浆中NO、CGRP、ET和抵抗素的水平。结果 与治疗前比较，高压氧与对照组治疗后血浆中NO[(84.61±25.64)、(56.41±22.53) mg/L]、CGRP[(51.71±12.98)、(35.98±10.47) mg/L]、ET[(55.94±9.65)、(75.14±11.23)mg/L]和抵抗素[(24.60±6.78)、(27.40±4.68) μg/L]水平均明显改善(P＜0.05)，且以高压氧组改善更加明显。高压氧组与对照组治疗后比较差异有统计学意义(P＜0.05或P＜0.01)。结论 高压氧能显著改善LVEF正常的心力衰竭患者的NO、CGRP、ET和抵抗素的代谢失衡，改善内皮细胞功能。

abstractsObjective To study the effect of HBO on the levels of plasma nitric oxide (NO), calcitonin gene-related peptide( CGRP), endothelin (ET) and resistin in the patients with heart failure and normal left ventricle ejection fraction. Methods A total of 67 patients with heart failure and normal ejection fraction were randomly divided into the control group ( n = 33) and the HBO group ( n = 34). Levels of plasma NO[(84.61 ±25.64)、(56.41 ± 22.53) mg/L]、CGRP[(51.71 ± 12.98)、(35.98 ± 10.47) mg/L]、ET [(55.94±9.65)、(75. 14 ± 11.23) mg/L]and resistin[(24.60 ±6.78)、(27.40 ±4.68) μg/L]were measured before and after treatment. Results After treatment, the levels of plasma NO, calcitonin gene-related peptide, endothelin and resistin in the patients with heart failure and normal ejection fraction improved obviously for both groups, with more significant improvement for the HBO group. Following treatment, statistical differences in the therapeutic effects could be seen, when comparisons were made between the HBO group and the control group( P ＜ 0. 05 or P ＜ 0. 01 ). Conclusions HBO could obviously improve the metabolic imbalance of NO, CGRP, ET and resistin and enhance the vascular endothelial function in the patients with heart failure and normal left ventricle ejection fraction.