摘要目的 探讨胶东地区渔民高尿酸血症的发生情况及与冠心病的关系.方法 调查接受冠脉造影的132例渔民和156例其他人群患者身高、体质量,同时测定血尿酸、血糖、血胆固醇、三酰甘油、高低密度脂蛋白,并根据冠脉造影结果将渔民人群分为冠心病组和对照组.结果 渔民的血尿酸平均为(377.3 ± 79.8) μmol/L,其他人群组血尿酸平均为(356.8±70.1) μmol/L,两者之间差异有统计学意义(P＜0.01);高尿酸血症的渔民脂代谢异常、糖尿病及肥胖的患病率明显高于尿酸正常渔民.Logistic回归分析结果显示,肥胖、饮酒、血脂紊乱是渔民高尿酸血症的危险因素,所有患者中大量饮酒者的血尿酸水平明显高于其他患者,差异有统计学意义(P＜0.01);132例渔民中,冠心病组血尿酸显著高于对照组(P＜0.01),单因素分析显示高尿酸血症是渔民冠心病发生的影响因素(OR=2.022,95％CI:1.098～3.723,Waldx2 =5.153,P=0.023).结论 渔民高尿酸血症患病率高于其他人群,血尿酸对渔民冠心病的发生有影响,应加强对渔民高尿酸血症的防治.

abstractsObjective To investigate the incidence of hyperuricemia among the fishermen in the Jiaodong region its relationship with the coronary heart disease (CHD).Methods A population survey of height and weight was made in 132 fishermen and 156 patients undergoing coronary angiography,at the same time,blood uric acid,blood sugar,cholesterol,triglycerides,as well as high/low density lipoprotein (HDL/LDL) were also determined in them.In accordance with the survey results,the fishermen were divided into the CHD group and the control group.Results The level of blood uric acid in the fishermen on the average was (377.3 ± 79.8) μmol/L,while the level of blood uric acid in the other population group was on the average (356.8 ± 70.1) μmol/L.Statistical significance could be seen,when comparisons were made between them (P ＜ 0.01).Lipid metabolism in the fishermen with high uric acid was abnormal,and rates of obesity and diabetes were also significantly higher than those of the fishermen with normal uric acid.Logistic regression analysis showed that obesity,alcoholism,blood lipid disorder were risk factors of hyperuricemia.Of all the patients,blood uric acid levels of heavy and moderate alcohol drinkers were all significantly higher than those of other patients,with statistical significance (P ＜0.01).In 132 fishermen,blood uric acid level in the coronary heart disease group was significantly higher than that of the control group (P ＜ 0.01).Single factor analysis indicated that hyperuricemia was a risk factor involved in the occurrence of CHD in fishermen(OR =2.022,95％ CI:1.098-3.723,Wald x2 =5.153,P =0.023).Conclusions Fishermen had a higher incidence of hyperuricemia than other population groups,and high blood uric acid was an influencing factor for the occurrence of coronary heart disease.For this reason,efforts should be made on the prevention and treatment of hyperuricemia in fishermen.