高压氧联合中药“蝎七方”改善急性脊髓损伤患者神经功能的临床观察
Clinical observation on the treatment of acute spinal cord injury with hyperbaric oxygen combined with traditional herbal medicine
摘要目的:探讨高压氧联合中药“蝎七方”治疗对急性脊髓损伤患者美国脊髓损伤协会( American spinal injury association , ASIA)痛觉和运动评分、Frankel分级评分的影响,评价临床疗效。方法60例急性脊髓损伤患者,为不完全性脊髓损伤。对照组(常规+高压氧治疗组)30例、治疗组(“蝎七方”+高压氧治疗组)30例。对照组给予常规药物治疗,有(或无)外科手术治疗,加高压氧疗法。治疗组在常规治疗加高压氧疗法基础上,给予中药“蝎七方”口服治疗。高压氧治疗方案:治疗压力0.2 MPa,稳压吸氧时间60 min。高压氧治疗1次/d ,连续治疗30 d。中药每日服用蝎七方1.5 g(3粒)2次,餐后口服,连续服用3个月。在治疗前、治疗后第10天、30天、60天、3个月的相同时间点,观察2组患者ASIA痛觉和运动评分、Frankel分级评分,评价总有效率。结果治疗组与对照组比较, ASIA痛觉评分在治疗后第30、60、90天差异有统计学意义( P<0.05);ASIA运动评分在治疗后第30、60、90天差异有统计学意义( P<0.01)。 Frankel总肌力评分在治疗后第30、60、90天差异有统计学意义( P<0.05),第10天差异有统计学意义(P<0.01);Frankel感觉评分在治疗后第30、60天差异有统计学意义(P<0.05),第10、90天差异有统计学意义(P<0.01)。治疗组总有效率为86.7%。结论高压氧结合中药“蝎七方”治疗,明显提高治疗的有效率,促进临床神经功能恢复,为中西医结合治疗急性脊髓损伤提供了临床依据。
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abstractsObjective To investigate the effects of hyperbaric oxygen ( HBO ) combined with herbal“scorpion seven” on the ASIA pain and motion scores and Frankel classification scores in the patients with acute spinal cord injury ( ASCI ) , and also to evaluate the clinical effects of the treatment .Methods Sixty patients with incomplete spinal cord injury were chosen for our study , and were divided into the control group (treated with conventional therapy +HBO) and the treatment group (treated with scorpion seven +HBO). At the same time points of the 10th, 30 th, 60 th days and the third month , close observations were made on the scores of ASIA pain and motion scores and Frankel classification scores , and evaluations were also made on the total effective rate .Results Following 30, 60 and 90 days of treatment , significant differences could be seen in the Asia pain scores in the treatment group , as compared with those of the control group (P<0.05). There were also significant differences in ASIA motion scores after 30, 60 and 90 days of treatment, when comparisons were made between the 2 groups (P<0.01).There were also significant differences in Frankel total muscle scores after 30, 60 and 90 days of treatment(P<0.05), and significant differences could be noted in Frankel total muscle scores at day 10 (P<0.01).Significant differences could be found in Frankel sensory scores in the treatment group, following 30 and 60 days of treatment(P<0.05), and significant differences could also be noticed in Frankel sensory scores at day 10 and day 90(P<0.01).Total effective rate for the treatment group was 86.7%.Conclusions HBO combined with herbal "scorpion seven"could significantly improve effective rate of the treatment , promote neurological function recovery clinically , and it would provide clinical evidence for the treatment of acute spinal cord injury by combining traditional herbal medicine with Western medicine .
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