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目的 观察高压氧对冠心病合并糖尿病患者经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)预后的影响.方法 回顾性分析我院实施PCI术的冠心病合并糖尿病患者123例,按治疗方法分为对照组(n =62例)和高压氧组(n=61例).对照组给予常规治疗,高压氧组在常规治疗基础上加用高压氧治疗.所有患者PCI术后随访3年,记录主要不良心脑血管事件(包括死亡、非致死性心肌梗死、再次血运重建、卒中、心绞痛及心衰)的发生情况.结果 对照组和高压氧组患者的临床基线资料差异无统计学意义(P＞0.05).PCI术后3年,高压氧组心绞痛发生率为6.56％,再次血运重建率为4.92％,总计主要不良心脑血管事件发生率为18.03％,均显著低于对照组(分别为20.97％、16.13％和45.16％),差异均有统计学意义(P＜0.05).结论 高压氧治疗可减少冠心病合并糖尿病患者PCI术后不良心脑血管事件.

Objective To observe the effects of hyperbaric oxygen (HBO) on the prognosis of the patients with coronary artery disease (CAD) complicated with diabetes mellitus (DM) after percutaneous coronary intervention (PCI).Methods A retrospective analysis was made on the 123 patients with CAD complicated with DM.The patients were assigned to the hyperbaric oxygen group (n =61) and the control group (n =62),in accordance with different treatment methods.The patients of the control group were given routine treatment,while the patients of the HBO group received HBO therapy in addition to routine treatment.All the patients had 3-year medical follow-ups,during which main adverse cardiovascular and cerebrovascular events were recorded,including death,nonfatal myocardial infarction,repeated revascularization,stroke,angina cordis and heart failure.Results There were obvious differences in the baseline clinical data in the patients of the control group and the HBO group,and statistical significance could not be noted,when comparisons were made between them (P ＞ 0.05).Three years after percutaneous coronary intervention,the incidence of angina cordis was 6.56％,repeated revascularization was 4.92％,and total major adverse cardiovascular and cerebrovascular events were 18.03％ in the patients of the HBO group,which were all significantly lower than those of the control group,which were respectively 20.97％,16.13％ and 45.16％.Statistical significance could be seen,when comparisons were made between them (P ＜ 0.05).Conclusions HBO could significantly lower adverse cardiovascular and cerebrovascular events in the patients with CAD complicated with DM following percutaneous coronary intervention.