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目的 研究姜酚鼻凝胶的抗运动病效果.方法 采用大鼠条件性厌食模型,观测旋转刺激前后大鼠糖精水摄入量;观测Beagle犬旋转刺激后流涎、呕吐的潜伏期,评价姜酚鼻凝胶抗运动病疗效.结果 旋转刺激前,各组大鼠糖精水饮用量无差别,旋转刺激后,对照组糖精水饮用量较旋转前明显减少(P<0.01).给药前,所有Beagle犬对于旋转刺激均敏感,流涎、呕吐出现时间较早;药物处理后,与对照组比较,给药中、高剂量组流涎及呕吐潜伏期均有显著延长,差异有统计学意义(P<0.05),流涎潜伏期延长至(17.89±8.42)min和(18.58±9.92)min,呕吐潜伏期延长至(25.50±12.78)min和(27.47±10.25)min.结论 通过鼻腔滴注姜酚凝胶具有一定的抗运动病作用.

Objective To study the effects of nasal gingerol gel on motion sickness .Methods The effects of nasal gingerol gel on motion sickness were evaluated by using the rat model of conditioned taste to observe changes in the amount of saccharine water intake , and also the Beagle dog model to observe the latent period of salivation and vomiting, before and after rotational stimulation.Results Before rotational stimulation, there were no significant differences in the amount of saccharine water intake in the rats of the groups . However, following rotational stimulation, the amount of saccharine water intake in the rats of the control group was obviously reduced, as compared with that before stimulation (P <0.01).Before drug treatment, all the Beagle dogs were susceptible to rotational stimulation , displaying early salivation and vomiting .However, after medication, the latent period of salivation and vomiting was all considerably delayed , as compared with the control group(P <0.05).The latent period of salivation of middle and high medication groups were extended to (17.89 ±8.42) min and (18.58 ±9.92) min, respectively.And the laent period of vomition of middle and high medication groups were extended to (25.50 ±12.78) min and (27.47 ±10.25) min.Conclusions Nasal gingerol gel showed certain protective effects against motion sickness .