摘要目的 探讨氟哌噻吨美利曲辛(黛力新)治疗肠易激综合征(irritable bowel syndrome,IBS)与功能性消化不良(functional dyspepsia,FD)重叠征患者的疗效.方法 选择上海市虹口区江湾医院2014年3月至2017年12月收治的IBS与FD症状相重叠的患者128例,按数表法随机分成对照组和观察组,每组64例.对照组给予匹维溴胺和奥美拉唑治疗,观察组给予黛力新治疗,对比分析2组患者疗效、汉密尔顿焦虑量表(HAMA)评分和汉密尔顿抑郁量表(HAMD)评分的差异性.结果 观察组总有效率96.7％,明显高于对照组,差异有统计学意义(P＜0.01);干预后观察组患者HAMD、HAMA评分明显下降,与对照组比较差异有统计学意义(P＜0.01).结论 黛力新治疗IBS与FD重叠征患者疗效确切,可有效改善临床症状,减轻焦虑抑郁程度,值得在临床推广.

abstractsObjective To investigate the efficacy of antidepressant Deanxit in the treatment of irritable bowel syndrome (IBS) and functional dyspepsia (FD) overlap syndrome.Methods One hundred and twentyeight patients with IBS and FD overlap syndrome admitted into the Jiangwan Hospital of Hongkou District,Shanghai for medical treatment from March,2014 to December,2017 were randomly divided into the control group and the observation group,each consisting of 64 patients.The control group received pinaverium bromide and omeprazole,while the observation group was treated with Deanxit.The differences in the efficacy,the Hamilton anxiety rating scale(HAMA) and the Hamilton depression rating scale (HAMD) were compared and analyzed between the patients of the 2 groups.Results Total effective rate of the observation group was 96.7％,which was significantly higher than that of the control group,and statistical significance could be seen when comparisons were made between the 2 groups (P ＜ 0.01).After intervention,both the HAMD and HAMA scores in the observation group decreased notably and were significantly lower than those in the control group,with statistical significance (P ＜ 0.01).Conclusion Deanxit could achieve sure results in the treatment of IBS and FD overlap syndrome,effectively improve clinical symptoms and relieve anxiety or depression.Therefore,it is worth clinical promotion.