摘要目的:分析高压氧（HBO）联合药物治疗突发性聋（SSHL）的疗效及相关影响因素。方法:选取2017年1月至2019年6月在解放军第九七一医院确诊为SSHL并进行治疗的患者310例，随机分为对照组（154例）和观察组（156例）。对照组给予单纯药物治疗，观察组给予HBO联合药物治疗。比较2组的临床疗效，采用秩和检验法对观察组中有效与无效患者的性别、年龄、合并糖尿病、高血压、开始治疗时间、听力损失曲线类型和听力损失程度进行显著性检验，并采用Logistic回归模型确立影响疗效的独立因素。结果:观察组总有效率为80.33%，对照组总有效率为66.90%，2组比较差异有统计学意义（ P<0.05）。观察组患者中，有效与无效者在性别、糖尿病、高血压方面比较，差异无统计学意义（ P>0.05）；在患者的年龄、开始治疗时间、听力损失曲线类型、听力损失程度方面的比较，差异有统计学意义（ P<0.05）。Logistic回归分析结果显示，开始治疗时间、听力损失曲线类型是HBO综合治疗SSHL的独立影响因素。 结论:HBO联合药物治疗SSHL疗效确切，患者开始治疗时间和听力损失曲线类型是HBO联合药物治疗SSHL临床疗效的影响因素。

abstractsObjective:To investigate the clinical efficacy of hyperbaric oxygen（HBO）comprehensive treatment of sudden sensorineural hearing loss（SSHL）and the related influencing factors.Methods:A total of 310 SSHL patients admitted to PLA No.971 Hospital from January 2017 to June 2019 were selected and divided into control group（ n=154）and observation group（ n=156）. The control group was on medication only，while the observation group was treated with medication combined with HBO. The therapeutic effects were compared between the two groups. The rank sum test was adopted to test the significance of gender，age，comorbid diabetes mellitus（DM），hypertension，onset to treatment time（OTT），type of hearing loss curve，and degree of hearing impairment between the patients whose treatment was effective and those whose treatment was ineffective in the observation group. Logistic regression was used to analyze the independent factors affecting the prognosis. Results:After treatment，the total effective rate was 80.33% in the observation group and 66.90% in the control group，and there were statistically significant differences between the two groups（ P<0.05）. Among the patients in the observation group，there was no statistically significant difference between those whose treatment was effective and those whose treatment was ineffective in terms of gender，DM，and hypertension（ P>0.05），while there were statistically significant differences in terms of age，OTT，type of hearing loss curve，and degree of hearing loss（ P<0.05）. The results of logistic regression analysis showed that the OTT and the type of hearing loss curve were the independent influencing factors for the HBO comprehensive treatment of SSHL. Conclusion:HBO comprehensive treatment has obvious curative effects in treating SSHL. The OTT and the type of hearing loss curve are the influencing factors of the clinical efficacy of HBO combined with medication in treating SSHL．