摘要目的:研究远程航行对作业人员血清总抗氧化能力（T-AOC）和肿瘤坏死因子-α（TNF-α）等指标的影响，以及姬松茸多糖（ABMP）联合维生素C对其改善效果。方法:采用简单随机法将60例某单位远航作业（40 d）人员按1∶1分为干预组和对照组，每组30例。干预组在远航期间，每日服用ABMP 400 mg、维生素C 100 mg进行营养干预，对照组服用淀粉安慰剂，服用期均为40 d。2组于远航前后各抽取空腹静脉血1次，检测血常规、T-AOC、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）、TNF-α、红细胞溶血度、淋巴细胞增殖活性等指标。结果:远航前，对照组和干预组T-AOC、GSH-Px、MDA、TNF-α、淋巴细胞增殖活性和红细胞溶血度差异无统计学意义（ P>0.05）。远航后，对照组T-AOC、GSH-Px、淋巴细胞增殖活性较远航前降低，而MDA、红细胞溶血度和TNF-α升高；干预组远航后的T-AOC、GSH-Px和淋巴细胞增殖活性较对照组升高，而MDA、TNF-α和红细胞溶血度较对照组降低，差异均有统计学意义（ P<0.05）。 结论:远程航行可造成作业人员T-AOC和TNF-α等指标的变化，ABMP联合维生素C的应用可提高远航人员机体抗氧化能力和免疫调节水平。

abstractsObjective:To investigate the effect of long oceangoing voyages on the indicators such as total antioxidant capacity（T-AOC）and tumor necrosis factor-alpha（TNF-α）in voyagers，and evaluate the improvement effects of the Agaricus blazei Murill polysaccharide（ABMP）combined with vitamin C（VitC）on those indicators. Methods:A total of 60 cases of voyagers on a long oceangoing voyage（40 d）from a certain unit were randomly divided into intervention group and control group，with 30 cases in each group. During the 40-day voyage，the intervention group took 400 mg of ABMP and 100 mg of VitC each day as nutritional intervention，while the control group took starch as placebo. Fasting venous blood was taken from both groups before and after voyage for routine blood test and detecting plasma T-AOC，malondialdehyde（MDA），glutathione peroxidase（GSH-Px），TNF-α，red blood cell hemolysis，lymphocyte proliferation activity，and other indicators.Results:Before the voyage，there was no statistically significant difference in T-AOC，GSH-Px，MDA，TNF-α，lymphocyte proliferation activity，or red blood cell hemolysis between the two groups（ P>0.05）. After the voyage，T-AOC，GSH-Px，and lymphocyte proliferation activity of the control group decreased compared with those before the voyage，while MDA，red blood cell hemolysis，and TNF-α increased compared with those before the voyage. The T-AOC，GSH-Px，and lymphocyte proliferation activity of the intervention group were higher than those of the control group after the voyage，while the MDA，TNF-α and red blood cell hemolysis were lower than those in the control group，and all the differences were statistically significant（ P<0.05）. Conclusion:Long oceangoing voyage can cause changes in T-AOC，TNF-α，and other indicators of voyagers. ABMP combined with VitC can improve their antioxidant capacity and immunoregulation level.