摘要目的:评估脑电图结合血清胱抑素C（CysC）对重症病毒性脑炎患儿高压氧联合康复治疗的预后价值。方法:选取2018年6月至2020年6月河南大学淮河医院儿科收治的88例重症病毒性脑炎患儿作为研究对象，均予以高压氧联合康复治疗。根据治疗后患儿的预后情况分为预后良好组（ n=31例）和预后不良组（ n=57）。对影响重症病毒性脑炎患儿治疗预后的相关因素进行单因素和多因素Logistic回归分析，并绘制受试者工作特征（ROC）曲线，评估脑电图结合血清CysC对重症病毒性脑炎患儿高压氧联合康复治疗的预后价值。 结果:单因素分析结果显示，惊厥持续状态、脑电图异常、血清CysC水平升高与患儿治疗预后有关（ P<0.05或 P<0.01）。多因素Logistic回归分析结果显示，惊厥持续状态（ OR=1.436；95% CI：1.077～1.916）、脑电图（ OR=4.175；95% CI：1.483～11.750）、血清CysC（ OR=1.244；95% CI：1.012～1.528）是重症病毒性脑炎患儿高压氧联合康复治疗预后的独立危险因素。脑电图结合血清CysC预测患儿治疗预后的敏感度和特异度分别为86.34%和72.51%。 结论:脑电图结合血清CysC对重症病毒性脑炎患儿高压氧联合康复治疗预后具有较高的敏感度和特异度，可作为临床疗效的预测指标。

abstractsObjective:To investigate the predictive value of electroencephalogram（EEG）combined with serum cystatin C（CysC）for the prognosis of children with severe viral encephalitis after hyperbaric oxygen combined with rehabilitation therapy.Methods:A total of 88 children with severe viral encephalitis admitted to Huaihe Hospital of Henan University from June 2018 to June 2020 were selected as the study subjects，who were all treated with hyperbaric oxygen combined with rehabilitation. According to the prognosis after treatment，the children were divided into good prognosis group（ n=31）and poor prognosis group（ n=57）. Single-factor logistic regression analysis and multiple-factor logistic regression analysis were carried out on the related factors affecting the prognosis of the children with severe viral encephalitis，and ROC curve was drawn to evaluate the predictive value of EEG combined with serum CysC on the prognosis of the patients after hyperbaric oxygen combined with rehabilitation therapy. Results:The single-factor analysis showed that the convulsion，abnormal EEG，and abnormal increase of serum CysC level were related to the prognosis（ P<0.05 or P<0.001）. The multiple-factor logistic regression analysis of the factors affecting the prognosis showed that convulsion（ OR=1.436；95% CI：1.077 to 1.916），EEG（ OR=4.175；95% CI：1.483 to 11.750），and serum CysC level（ OR=1.244；95% CI：1.012 to 1.528）were independent risk factors for the prognosis of the children after hyperbaric oxygen combined with rehabilitation treatment. The sensitivity and specificity of EEG combined with serum CysC level in predicting treatment outcome were 86.34% and 72.51%，respectively. Conclusion:EEG combined with serum CysC is of good predictive value for the prognosis of children with severe viral encephalitis after hyperbaric oxygen combined with rehabilitation therapy，owing to its high sensitivity and specificity，which can be adopted as an index for predicting clinical therapeutic effect.