换一批核因子-κB通路在甲状腺癌发生机制和治疗中的作用
The role of nuclear factor-κB pathway on carcinogenesis and therapy of thyroid cancer
摘要甲状腺癌的发病率逐年增高,131I治疗DTC虽是一种有效的治疗手段,但甲状腺癌的核素治疗失效也并不罕见.核因子-κB(NF-κB)在甲状腺癌细胞中的高表达与甲状腺癌的发生、进展、拮抗凋亡和产生耐药等均密切相关.NF-κB抑制剂对于甲状腺癌有明确的治疗效果,131I联合NF-κB抑制剂治疗可以增加对甲状腺癌的疗效.
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abstractsThe incidence rate of thyroid cancer is increasing very rapidly during the past years.131I treatment for DTC is an effective method.However,DTC refractory to 131I treatment or therapeutic failure is not uncommon.High level expression of nuclear factor-kappa B (NF-λB) in thyroid cancer is closely related with carcinogenesis,progression,anti-apoptosis and therapeutic resistance.NF-κB inhibitor was effective for the treatment of thyroid cancer.Combined NF-κB inhibitor with131I may improve the therapeutic efficacy.
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栏目名称
DOI
10.3760/cma.j.issn.2095-2848.2014.05.021
发布时间
2014-11-18（万方平台首次上网日期，不代表论文的发表时间）
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- 被引2
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