摘要脑胶质瘤因其浸润性生长和恶性生物学特性，临床治疗面临巨大挑战。实现肿瘤最大范围的安全切除是提升治疗效果与患者生存质量的关键。然而，目前临床术中可视化辅助技术存在灵敏度不足及准确性欠佳等局限。近年来，无标记拉曼光谱技术凭借其非侵入性、诊断迅速且准确性高等优势，不仅能准确诊断肿瘤和精准识别肿瘤浸润边界，还能判定肿瘤分子分型，为胶质瘤手术提供更为快速、精确的指导。该综述介绍无标记拉曼光谱技术在脑胶质瘤手术领域的最新进展及应用状况。

abstractsGliomas, with their infiltrative growth and malignant potential, present considerable therapeutic challenges. Maximal safe resection is essential for optimizing patient survival and quality of life. Despite this, existing intraoperative visualization techniques suffer from limited sensitivity and accuracy. Label-free Raman spectroscopy has emerged as a non-invasive, rapidly diagnostic, and highly accurate technique. It accurately diagnoses tumors, identifies infiltration margins, and classifies molecular subtypes, enhancing the precision of glioma surgery. This review summarizes the latest advances and applications of label-free Raman spectroscopy in glioma surgery.