摘要目的:分析鹦鹉热衣原体肺炎患者的临床表现及辅助检查特征，提高对该病的认识。方法:收集联勤保障部队第九〇〇医院2018年11月至2020年2月经宏基因组二代测序（mNGS）诊断的鹦鹉热衣原体肺炎患者8例，对其临床特征、实验室检查、影像和病理特征及治疗用药进行回顾性分析。结果:8例患者中，男1例，女7例，年龄45~85岁，中位年龄62岁；临床主要表现为高热（8/8），咳嗽（8/8），咳痰（6/8）。白细胞计数正常（7/8），淋巴细胞计数降低（5/8），CRP升高（8/8），ESR升高（7/8），PCT正常（5/8）。8例患者胸部CT均表现为大片斑片实变影，其中1例伴有胸腔积液。病理表现无特异性，均为炎症细胞浸润伴纤维素渗出。经mNGS确诊后使用多西环素、莫西沙星单药或两药联合的治疗方案，疗程14~21 d，复查胸部CT可见病灶均吸收。结论:鹦鹉热衣原体肺炎的临床表现具有一定的特征性，通常表现为高热伴肺部大片斑片实变影，白细胞计数正常。临床对可疑病例应积极行mNGS检测明确病原学诊断，快速过渡到目标治疗，可缩短患者的病程，改善预后。

abstractsObjective:In order to improve the understanding and clinical treatment of Chlamydia psittaci pneumonia, we analyzed the clinical manifestations, laboratory test results and imaging features of 8 patients. Methods:We collected the clinical data of 8 patients with Chlamydia psittaci pneumonia diagnosed by metagenomic next-generation-sequencing (mNGS) from November 2018 to February 2020, including clinical features, chest CT scan, pathological features and antibiotic use. Results:A total of one male and 7 females, aged from 45 to 85 years(median 62 years), were included in this study. All the patients had high fever, cough and most had expectoration (6/8). The leukocyte count and PCT level were mostly normal (7/8). However, we observed decreased lymphocyte count(5/8), elevated C-reactive protein in all patients, and increased ESR in most patients (7/8). The chest CT of all the patients showed large patchy consolidation, with one case having pleural effusion. The pathological manifestations were nonspecific, showing infiltration of inflammatory cells and exudation. Moxifloxacin and/or doxycycline were administered after diagnosis, and the course of treatment lasted from 14 to 21 days.Chest CT showed absorption of lesions following treatmentConclusions:Chlamydia psittaci pneumonia showed certain characteristics, including high fever with pulmonary patchy consolidation, and normal white blood cell count. Molecular diagnostic methods such as mNGS could lead to rapid diagnosis and treatment which can shorten the course of hospitalization and thus improve prognosis.