摘要近年来，免疫治疗的兴起全面改变了晚期非小细胞肺癌的治疗格局。随着对肿瘤免疫微环境的研究渐深，常被临床研究排除在外的肺癌晚期脑转移患者逐渐被研究者们关注，从免疫单药治疗发展到免疫联合治疗，极大程度改善了脑转移肺癌患者的生存预后。本文旨在阐述转移灶的免疫微环境基础，同时回顾并总结近年来非小细胞肺癌脑转移免疫治疗的最新研究进展。

abstractsIn recent years, the rise of immunotherapy has comprehensively changed the treatment pattern of advanced non-small cell lung cancer(NSCLC). With the understanding of the immune microenvironment in brain metastasis, patients with advanced lung cancer with brain metastasis, who usually were previously excluded from clinical studies, gradually gained attention from researchers. The development from immune monotherapy to combination with chemotherapy significantly improved the survival prognosis of patients with brain metastases from lung cancer. This review aimed to briefly elucidate the mechanism of the immune microenvironment, and summarized the latest research progress of immunotherapy for NSCLC patients with brain metastasis.