摘要目前关于西藏高原地区急性肺栓塞患者系统性溶栓治疗的临床研究及病例报道非常少见，对于高原地区中高危急性肺栓塞患者的危险因素、临床特点和溶栓治疗等认识较少，缺乏临床经验。本文通过报道拉萨市人民医院收治的4例急性中高危肺栓塞溶栓治疗患者的病例资料，分析其人口学特点、临床特征、治疗和转归，总结临床现象，提出科学问题，为提升高原地区急性肺栓塞的规范化诊治水平提供基础数据，为今后开展此方面的临床研究指明方向。

abstractsAt present, clinical studies and case reports of systemic thrombolytic therapy for patients with acute pulmonary embolism in Tibet Plateau are very rare. There is little understanding of the risk factors, clinical characteristics, and thrombolytic therapy for patients with acute pulmonary embolism at intermediate-high risk in Tibet Plateau. In this paper, we reported the data of 4 patients with acute intermediate-high risk pulmonary embolism treated with thrombolytic therapy in Lhasa People′s Hospital. The demographic characteristics, clinical manifestations, treatment, and outcomes were analyzed. We summarized the clinical features and raised scientific issues. We aimed to provide basic data to improve the standardized diagnosis and treatment of acute pulmonary embolism in plateau, and to point out the direction of future clinical research in this field.