摘要SWI/SNF染色质重塑复合物BAF亚基（SMARCB1）缺失性肺癌罕见，可能适合免疫治疗。本文报道1例老年男性患者，因无明显诱因干咳3个月就诊，经支气管镜活检病理检查提示非小细胞肺癌，免疫组织化学染色SMARCB1（-）、SMARCA4（+）、PD-L1（22C3）肿瘤细胞阳性比例评分（TPS）为60%、Ki-67（+）阳性指数为60%，诊断为SMARCB1缺失性肺癌，给予化疗联合免疫治疗，随访34个月，患者目前带瘤生存。

abstractsSWI/SNF chromatin remodeling complex BAF subunit (SMARCB1)-deficient lung carcinoma is rare and may be suitable for immunotherapy. This article presents the case of an elderly male who presented with "a persistent dry cough for 3 months without obvious inducement", and was initially diagnosed with non-small cell lung carcinoma following bronchoscopic biopsy. Immunohistochemical staining for SMARCB1 (-), SMARCA4 (+), PD-L1(22C3) (tumor proportion score is 60%), Ki-67 (+) with a positive index of 60%. The final diagnosis is SMARCB1-deficient lung carcinoma. He was subsequently treated once with a combination of chemotherapy and immunotherapy, and has been followed up for 34 months. Currently, the patient continues to survive with tumor.