摘要抗体介导排异反应（AMR）是肺移植术后排异反应的一种表现形式，是由于受者体内抗供者人类白细胞抗原（HLA）和（或）非HLA抗体导致的排异反应，根据是否存在移植物功能障碍表现分为临床型及亚临床型。本文报道1例双肺移植术后早期，以发热为主要表现的临床型AMR，经血浆置换及丙种球蛋白静点治疗后病情好转。

abstractsAntibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients due to the presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs). Here, we reported that a 69-year-old woman with underlying connective tissue disease-associated interstitial lung disease (CTD-ILD) developed recurrent fever with elevated white blood cells, C-reactive protein (CRP) and new ground-glass opacities on chest computed tomography (CT) early after double lung transplantation. After a thorough investigation for infection, rejection and relapse of primary immune diseases, the patient was found to be panel-reactive antibody (PRA) positive and DSAs positive. Pathology of the transbronchial lung biopsy (TBLB) revealed positive histology suggestive of AMR and positive C4d staining. The final diagnosis was definite clinical AMR. Following treatment with plasma exchange and intravenous immunoglobulin (IVIg) infusion, the patient′s condition improved significantly, and the patient was discharged from hospital.