摘要阻塞性睡眠呼吸暂停（OSA）是一种常见的异质性疾病。尽管多数患者能获得良好治疗，但仍有不少患者的治疗效果欠佳。生理学特征异常是OSA的重要病理生理学机制，对临床治疗具有指导意义。本文介绍了与OSA治疗效果相关的四种生理学特征以及对这些特征的检测方法，继而介绍基于这些特征对OSA治疗的指导意义，为OSA患者个体化治疗提供参考。

abstractsObstructive sleep apnea (OSA) is a common and heterogeneous disorder. Most patients can be successfully treated, but some have poor treatment outcomes. This review first presented four physiological OSA characteristics, including upper airway collapsibility, loop gain, airway muscle responsiveness, and arousal threshold, which are associated with the efficacy of OSA therapy. Then, we presented how to select the most effective therapy modality for each individual based on OSA characteristics, with the purpose of providing a basis for individualized treatment of OSA.