摘要目的 评价自创性健康危险因素的行为干预与管理在糖尿病前期人群预防或延缓糖尿病发生中的作用.方法 将空腹血糖受损及糖耐量减低的118例糖尿病前期体检者随机分组,其中实验组58例,对照组60例.实验组提供健康干预,包括糖尿病基本知识讲座,定期复查及检查的必要性及意义,合理的营养与膳食,减肥,体力活动及运动等方法.对照组仅告知空腹血糖受损或糖耐量减低.比较6个月、12个月后,实验组与对照组糖尿病前期转归及显性糖尿病发生的情况.结果 实施干预措施6个月后,实验组与对照组空腹血糖受损恢复正常的人数差异无统计学意义(x2=0.04,P=0.84),糖耐量异常恢复正常的人数差异无统计学意义(x2=0.79,P=0.12),转为显性糖尿病的人数差异也无统计学意义(x2=0.96,P=0.33);实施干预措施12个月后,两组空腹血糖受损恢复正常及糖耐量异常恢复正常的人数差异都有统计学意义(x2=13.34,22.58;均P<0.01),但转为显性糖尿病的人数差异无统计学意义(x2=2.83,P=0.09).结论 对糖尿病前期人群进行自创性危险因素管理能预防或延缓糖尿病发生,提高生活质量.

abstractsObjective To evaluate the value of health intervention to changeable risk factors in persons with diabetes prophase.Methods One hundred and eighteen persons in diabetes prophase were divided into two groups randomly.For 58 persons enrolled in the experimental group,health intervention including lectures of diabetes basic knowledge,introducing the necessity and significance of periodical check up and examination,suitable dietary and nutrition,weight control,physical exercise and movement was performed.For 60 persons enrolled in the control group,only the diagnosis of diabetes prophase was informed.The incidence of normalization of blood glucose and progressing to dominant diabetes was compared between the experimental group and the control group after follow-up for 6 months and 12 months.Results After 6 months of intervention,the difference of the number of persons was not significant for normalization of blood glucose between experimental group and control group(x2=0.04 and 0.79,P=0.84 and 0.12 for persons with IFG and IGT respectively),and was also not significant for progressing to dominant diabetes between the two groups(x2=0.96,P=0.33).After 12 months of intervention,the difference of the number of persons was significant for normalization of blood glucose between experimental group and control group(x2=13.34 and 22.58,P<0.01 and<0.01 for persons with IFG and IGT respectively),but still not significant for progressing to dominant diabetes between the two groups(x2=2.83,P=0.09).Conclusions The intervention to changeable risk factors can prevent or delay the occurrence of diabetes mellitus,and improve the quality of life for person with diabetes prophase.