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目的 通过对健康体检中非酒精性脂肪性肝病(NAFLD)人群与行为因素进行调查,研究其生活行为和疾病因素可能与NAFLD发病的相关性,并提出干预性防治措施.方法 选择2038例健康体检者(包括1438例NAFLD患者)采用问卷调查的形式对其生活行为和疾病因素调查研究,并进行包括超声检查、肝功和血脂检测在内的常规体检,根据体检和问卷结果进行综合分析判断.结果 多因素非条件Logistic回归分析结果表明:NAFLD患者男性20～49岁居多(76.5%).工作压力大、睡眠过多、运动减少,高脂肪高蛋白饮食、喜好油煎炸、辛辣、甜食、冷饮、临睡前加餐等,体重指数和腰臀比值增加,伴随肥胖症、高血脂、高血压病、糖尿病、冠心病以及遗传和家族史等因素均与NAFLD的发病呈正相关(P＜0.05).结论 NAFLD的发病以男性青中年为主,且与多种生活行为和疾病因素密切相关,单纯性NAFLD是可逆性的,通过改变饮食结构、生活方式和控制原发基础疾病或伴随疾病等,可使NAFLD得到改善,甚至消失.

Objective To study the behavior factors associated with nonalcoholic fatty liver disease (NAFLD).Methods A total of 2038 subjects who underwent physical examination at the Department of Health check-up center,the Affiliated Hospital of Medical College,Qingdao University were included in this study(including 1438 cases of NAFLD).A questionnaire survey was conducted on their lifestyle and behaviors.Data of routine physical examination,ultrasound examination,liver function and blood lipid test were collected and analyzed.Results Multi-factors Logistic regression analysis showed that age (20 to 49 years) male sex,stress from work,sleep time, physical activity and diet axe among factors associated with NAFLD(all P＜0.05).Conclusion Lifestyle and behavior factor are associated with the incidence of NAFLD.