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目的 探讨血清唾液酸(SA)水平对消化系统恶性肿瘤诊断价值,并作为一种消化系统肿瘤标志物与癌胚抗原(CEA)指标进行比较.方法 采用同顾性病例对照研究方法,对60例健康人,100例消化系统恶性肿瘤患者及部分肿瘤切除后患者,以酶法检测血清唾液酸含量,以化学发光法检测血清CEA含量.以病理检查结果为金标准,计算SA和CEA在消化系统恶性肿瘤诊断中的灵敏度和特异度,通过受试者工作曲线下面积(ROC-AUC)评价SA的诊断价值.结果 消化系统恶性肿瘤患者血清唾液酸含量明显高于正常对照组(=7.314,P＜0.05),而肿瘤切除后2～3个月患者血清唾液酸含量与健康对照组差异无统计学意义(t =0.404,P＞0.05),但与治疗前比较SA含量显著降低,差异有统计学意义(t =3.55,P＜0.05).血清唾液酸诊断消化系统恶性肿瘤灵敏度为55.0％,特异性为93.3％；诊断正常人血清假阳性率为6.7％.结论 血清中唾液酸检测在消化系统恶性肿瘤筛查、诊断、术后疗效评估及监测均有重要意义.与CEA相比无明显差异.

Objective To investigate serum levels of sialic acids(SA)vs carcino-embryonic antigen(CEA)for the diagnosis of digestive tract cancer.Methods Sixty healthy adults,100 patients with malignant digestive tract tumor and those undergoing radical digestive tract tumor surgery were enrolled in this case-control study.Serum SA level was tested.Serum CEA level was measured by electrochemical luminescence.Sensitivity and specificity of SAvs CEA were calculated.Receiver operating characteristic (ROC)curve and area under the curve(ROC-AUC)were used to evaluate the diagnostic value of SA.Results Serum level of SA of patients with digestive malignant tumors was much higher than the normal controls(P ＜0.01),although serum SA of patients undergoing tumor resection showed no difference with the normal controls(P ＞ 0.05).There was significant difference in SA level between the patients who received surgical therapy or not.The sensitivity and specificity of SA in diagnosing digestive tract cancer was 55.00％ and 93.3％,respectively.The false positive rate was 6.7％ in normal subjects.Conclusion Serum SA or CEA testing may be equally useful in the screening,diagnosis,outcome assessment and followup study of digestive tract cancer.