摘要目的 超重和肥胖已成为影响青少年健康的关键问题.本研究探讨饮食及运动干预对青少年体内氧化应激状态的影响.方法 124名受试者中的93名超重及肥胖青少年年龄(13.6±0.7)岁,体重指数(BMI 22.4 ～ 34.1 kg/m2)随机分为四组:饮食干预组(D)、运动干预组(E)、饮食运动干预组(DE)、超重及肥胖对照组(O).饮食方案根据研究对象的年龄及理想体重制定；运动干预为放学后1h中等强度运动,每周4次.干预周期为10周,干预前后分别进行人体测量、身体成分、代谢及氧化应激等指标检测.31名正常体重者为对照组.结果 超重及肥胖组的空腹血糖、TC、LDL-C和MDA水平明显高于正常体重组(P＜0.05),SOD水平低于正常体重组(P＜0.05)；MDA水平与体重、BMI、TC、LDL-C呈正相关(R=0.209,0.228,0.274,0.263,P＜0.05),SOD与体重及BMI呈负相关(R=-0.334,-0.362,P＜0.05)；干预后D、E、DE组BMI、腰围、全身脂肪显著下降(P＜0.05),D和E组的MDA水平下降(P＜0.05)；两个运动干预组的TC和LDL-C下降亦达统计学差异(P＜0.05).结论 超重青少年在糖脂代谢正常阶段体内即存在氧化应激失衡状态.为期10周的饮食和(或)运动的生活方式干预在改善青少年超重状态、调节血脂水平的同时,还可显著降低其体内的氧化应激水平.

abstractsObjective To explore the effects of diet and/or exercise intervention on oxidative stress of overweight or obese adolescents.Methods Thirty-one adolescents with normal body weight(normal control group)and 93 overweight or obese adolescents(average age(13.6 ±0.7)years; body mass index (BMI)22.4 to 34.1 kg/m2)were enrolled in this study.The overweight or obese participants were then randomly assigned to the diet group(group A),exercise group(group B),diet plus exercise group(group C),and non-intervention group(group D).Individualized caloric intake was carried out.One-hour afterschool exercise was performed once per day,4 days per week for 10 weeks.Changes of anthropometry,body composition,and metabolic biomarkers were determined.Results Compared to the normal control group,serum levels of fasting glucose,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and malondialdehyde(M DA)of the in overweight group were significant increased(all P ＜ 0.05),although the level of SOD was significant decreased(P ＜ 0.05).Serum MDA level was positively correlated with bodyweight,BMI,TC,and LDL-C(R values were 0.209,0.228,0.274,and 0.263,respectively ; all P ＜0.05),and serum SOD level was negatively correlated with bodyweight and BMI(R values were-0.334 and-0.362,respectively ; both P ＜ 0.05).Group A,B and C showed a significant decrease in BMI,waist circumference and body fat after the intervention(all P ＜ 0.05).The level of MDA was significantly decreased after the intervention in group A and B(both P ＜ 0.05); the levels of TC and LDL-C were significantly decreased in group B and C(both P ＜ 0.05).Conclusion:Oxidative stress could have existed in overweight adolescents even when their serum glucose and lipid profiles are at a normal level.Ten-week diet and/or exercise intervention may contribute to improved body weight control,lipid metabolism,and oxidative stress response in this population.