摘要目的 探讨健康体检人群食物不耐受的流行现状及相关影响因素.方法 采用酶联免疫法检测863例健康体检者血清中14种食物过敏原特异性IgG抗体,并进行分级,同时测量体检者的身高、体重、血压等指标.结果 本地区体检人群14种食物不耐受总体阳性率为73％,位于前5位的不耐受种类分别是螃蟹(40.1％),鸡蛋(29.8％),鳕鱼(21.6％),牛奶(20.0％)和虾(14.4％).女性的食物不耐受阳性率(81.1％)明显高于男性(69.1％).牛奶、大豆在不同年龄组人群中的不耐受发生率不同且差异有统计学意义,其他食物的不耐受率在不同年龄组间无显著差异.BMI、收缩压和舒张压与14种食物的特异性IgG抗体浓度间无明显相关性.logistic回归分析显示,女性发生食物不耐受的危险度是男性的1.76倍(95％ CI为1.190 ～2.607).结论 14种食物不耐受的发生率较高,女性发生不耐受的危险高于男性.建议在体检人群中开展食物特异性IgG抗体的检测,及时明确不耐受食物,以早期预防和诊治因食物不耐受引起的各种疾病和症状.

abstractsObjective To study the prevalence of food intolerance and to explore its related factors among adult health check-up receivers.Methods A total of 863 adults who took physical examinations in our hospital from April to October 2011 were enrolled in this investigation.Height,body weight and blood pressure were measured,and serum IgG level was measured by enzyme-linked immunosorbent assay (ELISA).Results The total positive rate of food intolerance was 73％,and the leading intolerance items were crab (40.1％ ),egg (29.8％ ),cod fish ( 21.6％ ),milk ( 20.0％ ) and soybean ( 14.4％ ).Females showed significantly higher prevalence of food intolerance than males.Various positive rate of milk or soybean intolerance was found in different age groups.No correlations of serum specific IgG with body mass index and systolic or diastolic blood pressure were observed.In logistic regression analysis,the odds ratio of food intolerance of women was 1.67 ( 95 ％ confidence interval 1.190 to 2.607 ).Conclusions The prevalence rate of food intolerance was high.The risk for food intolerance was significantly increased in women.Specific IgG antibody detection may help to early prevent and diagnose food intolerance-related diseases.