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目的：探讨中性粒细胞/淋巴细胞比值（NLR）与2型糖尿病的关联。方法对象为2007至2013年在天津医科大学总医院健康管理中心接受健康体检的人群，其中男性49861人，女性40376人。2型糖尿病的诊断标准为，已经诊断糖尿病或空腹血糖≥7 mmol/L。统计方法采用多元logistic回归模型评估NLR五分位和2型糖尿病患病率的关联。结果2型糖尿病的患病率为5.1%。在男性，伴随着NLR值的增加，调整后2型糖尿病比值比（95%置信区间）分别为1.00（参考值），1.19（1.05，1.35），1.33（1.17，1.50），1.28（1.13，1.44）和1.34（1.19，1.51）（趋势性P值<0.0001）。女性：1.00（参考值），1.18（0.97，1.45），1.02（0.83，1.25），1.21（0.99，1.48）和1.53（1.27，1.86）（趋势性P值<0.0001）。结论在男性和女性中，NLR与2型糖尿病的患病率均呈正相关。

Objective Neutrophil/lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker but few studies have assessed the relationship between NLR and type 2 diabetes. In order to evaluate how NLR is related to type 2 diabetes, we designed a large scale cross?sectional study in an adult population. Method A cross?sectional study (including 49 861 men and 40 376 women) was conducted on participants recruited from the Health Management Center of Tianjin Medical University General Hospital in Tianjin, China. Measurements of neutrophil and lymphocyte counts, fasting blood glucose and other potential confounding factors were performed. Type 2 diabetes was defined according to the criteria of American Diabetes Association. Adjusted logistic regression models were used to assess relationships between NLR quintiles and type 2 diabetes. Result In the final multivariate models, the odds ratios (95% confidence interval) for T2D across NLR quintiles were 1.00 (Reference), 1.19 (1.05, 1.35), 1.33 (1.17, 1.50), 1.28 (1.13, 1.44) and 1.34 (1.19, 1.51) (P for trend<0.000 1), in men. Similar relationships were also observed in women. Conclusion This study demonstrated that NLR was related to the prevalence of type 2 diabetes in men and women, and suggesting that NLR may be an efficient and accurate prognostic biomarker for type 2 diabetes.