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目的：探讨中青年人群的血脂水平与人体成分之间的关系。方法根据人体成分检测结果，将642名受试者（21~60岁，男178人，女464人）分为正常（N）组272人，单纯肥胖（O）组245人和少肌症肥胖（SO）组125人，比较组间血脂谱的差异，并进行血脂异常的相关因素分析。结果 N组、O组、SO组的血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL?C）水平逐渐升高，高密度脂蛋白胆固醇（HDL?C）水平逐渐降低（P<0.01）；发生高TC、TG、LDL?C与低HDL?C血症的比值比逐渐升高[与N组相比，O组发生4项血脂异常的OR（95%CI）值分别为2.617（1.117~6.132）、3.549（1.481~8.503）、4.618（1.288~16.564）、1.222（0.529~2.822），SO组分别为5.915（2.512~13.926）、10.430（4.400~24.722）、9.522（2.637~34.388）、4.253（1.957~9.242）]；校正性别、年龄、腰臀比、内脏脂肪面积后，N组、O组、SO组发生高TG血症的比值比仍逐渐升高[与N组相比，O组的OR（95%CI）值为3.565（1.319~9.632），SO组为8.173（2.685~24.881）]。SO组发生高TC、低HDL?C血症的比值比也高于N组[OR（95%CI）值分别为5.658（1.871~17.111）、6.823（2.119~21.969）]。以有、无血脂异常为因变量分别对男性、女性进行多因素logistic回归分析发现，男性高TC、TG血症的关联因素分别是体脂百分比增加，少肌症、少肌症肥胖，低HDL?C血症的关联因素为少肌症；女性高TC、TG、LDL?C血症的关联因素分别为少肌症、增龄，体脂百分比增加、增龄，少肌症、增龄（P<0.05）。结论中青年人群中肥胖伴有相对肌肉减少者容易发生血脂异常，其严重程度高于单纯性肥胖者。肌肉相对减少是男性高TG、低HDL?C血症，女性高TC、高LDL?C血症的关联因素。

Objective To explore the relationship between lipids profile and body composition in the young and middle?aged adults. Method The relationship between body composition and lipids profile was examined in 642 adults (21-60 years, 178 male, 464 female). According to the result of body composition assessment, they were assigned to three groups: Normal (N, n=272), Obesity (O, n=245), Sarcopenic Obesity (SO, n=125). The lipids profile among three groups and its related factors were analyzed. Results In groups N, O and SO, the levels of total cholesterol (TC), triglycerides (TG), low density lipoprotein?cholesterol (LDL?C) increased gradually (P<0.01), and the high density lipoprotein?cholesterol (HDL?C) level decreased gradually (P<0.01). In a multiple logistic regression analysis, the odds ratio for high levels of TC, TG, LDL?C and low level of HDL?C risk increased gradually in groups N, O and SO [compared to group N, the odds ratio of the four kinds of dyslipidemia in group O were 2.617 (1.117-6.132), 3.549 (1.481-8.503), 4.618 (1.288-16.564), 1.222 (0.529-2.822), respectively, and in group SO were 5.915 (2.512-13.926), 10.430 (4.400-24.722), 9.522 (2.637-34.388) , 4.253 (1.957-9.242) , respectively]. After&nbsp;adjusting for age, sex, waist?to?hip ratio and visceral fat area, the odds ratio for high level of TG risk still increased gradually in group N, O and SO [compared to group N, the odds ratio of group O was 3.565 (1.319-9.632), and of group SO was 8.173 (2.685-24.881)]. Moreover, the odds ratio for high TC and low HDL?C levels of group SO were higher than those of group N [compared to group N, the odds ratio in group SO were 5.658 (1.871-17.111), 6.823 (2.119-21.969) respectively]. With stepwise multivariate logistic regression analysis, for male, the related factors for high levels of TC, TG and low level of HDL?C were high percentage of body fat;sarcopenia, sarcopenia obesity;sarcopenia, respectively. For female, the related factors for high levels of TC, TG and LDL?C were sarcopenia, aging;high percrntage of body fat, aging;sarcopenia, aging, respectively. Conclusion SO was the main risk factor for dyslipidemia in young and middle?aged adults, even more severe than obesity alone and sarcopenia was the risk factor of high TG, low HDL?C levels for male;and the risk factor of high TC, high LDL?C levels for female.