摘要目的：探讨老年人血清C反应蛋白（CRP）浓度与肌肉力量及身体活动能力之间的关系。方法采用横断面研究的方法设计，于2013年4—6月对天津市汉沽区1131名60岁及以上的老年人进行问卷调查、CRP检测、肌肉力量及身体活动能力测量。通过多元线性回归分析评估血清CRP浓度与肌肉力量之间的关系；采用多元logistic回归分析探讨血清CRP浓度三分位水平与身体活动能力之间的关系。结果在536名男性中，调整混杂年龄、体质指数、吸烟、饮酒、身体活动、高血压、糖尿病、心血管疾病、贫血、肿瘤史和体力活动等因素后，血清CRP对数转换值与肌肉力量呈负相关（标准回归系数=-0.11，P<0.01），血清CRP浓度三分位水平与身体活动能力的比值比（95%可信区间）分别为1.00，1.09（0.50，2.39）及2.70（1.34，5.66）（趋势性P值<0.01）。在595名女性中，CRP浓度与肌肉力量及身体活动能力的关系差异均无统计学意义。结论在老年男性中血清CRP浓度与肌肉力量和身体活动能力呈负相关，提示炎症信号通路在肌肉衰减征的发生发展过程中可能发挥着重要作用。

abstractsObjective The aim of this study was to investigate the relationship between serum C-reactive protein (CRP) and muscle strength, physical performance in the elderly. Methods A cross-sectional study was conducted in Hangu district of Tianjin from April to June in 2013. Totally 1 131 subjects aged 60 years or older completed the survey. Every subject filled out a standard questionnaire and underwent grip strength test, timed up and go test (TUGT). Serum CRP concentrations were determined using chemiluminescent immunoassay kits. Multivariate analysis was performed to determine the relationship between CRP and muscle strength, physical performance. Results After adjustment for potential confounding factors including age, BMI, smoking status, drinking status, hypertension, diabetes, cardiovascular disease, anemia, cancer and physical activity, the multiple linear regression analysis suggested that CRP levels were inversely related to handgrip strength (β'=-0.11, P<0.01), and the logistic regression analysis showed that compared with subjects in the lowest quintile, the odds ratios and 95%confidence interval of higher quintile of CRP were 1.09 (0.50, 2.39) and 2.70 (1.34, 5.66) (Ptrend<0.05) in males. However, the relationship between CRP and muscle strength, physical performance was not statistically significant in females. Conclusions In males, higher serum CRP levels were independently correlated with lower muscle strength and poor physical performance in older adults. These results suggested that inflammation-signaling pathways may play an important role in the progression of sarcopenia.