摘要目的:探讨微信小程序在儿童过敏性鼻炎-哮喘综合征（combined allergic rhinitis and asthma syndrome，CARAS）免疫治疗中的应用效果。方法:采用便利抽样法，选取2019年1月—2020年1月在郑州大学第一附属医院接受舌下免疫治疗的101例CARAS患儿作为研究对象，成立免疫治疗门诊规范化管理团队，运用新开发的特异性免疫治疗微信小程序，建立护患互动交流新模式，通过微信小程序定时推送疾病知识、信息提醒用药、护士电话干预等规范管理对患儿实施延续性护理。分析该管理模式对患儿用药依从性、鼻炎症状和哮喘控制水平的影响。结果:本研究共纳入患儿101例，失访3例，最终共98例完成研究。干预12个月后，98例患儿尘螨滴剂药物占有比得分由（83.43±3.68）升至（91.78±3.71）分，过敏性鼻炎症状评分由（5.83±1.32）降至（1.94±0.98）分，哮喘测试问卷评分由（18.12±3.99）升至（24.97±3.09）分；完全控制哮喘的患儿占比由48.0%升至90.8%，未控制哮喘的患儿占比由10.2%降至1.0%（均 P<0.05）。 结论:基于微信小程序的儿童CARAS的免疫治疗，能有效提高患儿及家长的依从性、提高患儿过敏性鼻炎和哮喘的控制水平。

abstractsObjective:To explore the effect of WeChat mini program in immunotherapy management of pediatric patients with combined allergic rhinitis and asthma syndrome (CARAS).Methods:Using the convenient sampling method, 101 children with CARAS who received sublingual immunotherapy in the First Affiliated Hospital of Zhengzhou University from January 2019 to January 2020 were selected as the research objects. The standardized management team of immunotherapy clinic was established. The newly developed specific immunotherapy Wechat applet was used to establish a new model of nurse-patient interaction and communication. The disease knowledge was regularly pushed, medication reminder, nurse telephone intervention and other standardized management were delivered through the Wechat applet to implement continuous nursing for children. The effects of this management model on medication compliance, rhinitis symptoms and asthma control were analyzed.Results:A total of 101 children were included in this study, 3 cases were lost to follow-up, and a total of 98 cases completed the study. After 12 months of intervention, the drug possession score of dust mite drops increased from (83.43±3.68) to (91.78±3.71), the symptom score of allergic rhinitis decreased from (5.83±1.32) to (1.94±0.98), and the score of asthma test questionnaire increased from (18.12±3.99) to (24.97±3.09), the proportion of children with complete control of asthma increased from 48.0% to 90.8%, and the proportion of children without control of asthma decreased from 10.2% to 1.0% (all P<0.05). Conclusion:The immunotherapy management of pediatric patients with combined allergic rhinitis and asthma syndrome based on WeChat mini program can effectively improve the compliance of children and their family, improve the control level of allergic rhinitis and asthma.