摘要目的:通过健康人群试验评价海洋鱼低聚肽维生素C固体饮料的抗氧化功能。方法:选取2017年6月1日—12月31日浙江省疾病预防控制中心招募的18~65岁身体健康状况良好的志愿者110例，采用简单随机分组分为对照组和试验组各55例。试验组服用海洋鱼低聚肽维生素C固体饮料（主要成分为海洋鱼低聚肽粉、维生素C、阿萨伊果粉、蓝莓果粉、石榴果粉），对照组服用外形包装口感均相同的安慰剂（主要成分为麦芽糊精、阿萨伊果粉、蓝莓果粉、石榴果粉），均为5 g/袋，1袋/d，连续服用4个月。试验期间两组均保持平日的生活和饮食习惯，除受试样品和安慰剂之外，无其他干预措施。干预过程中出组3例，最终纳入对照组53例，试验组54例。试验前、后分别对两组志愿者进行身体一般情况检查，血、尿、便常规以及生化指标检查，同时进行血丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）水平测定，采用 t检验比较两组试食前后各项指标差异。 结果:两组基线资料差异均无统计学意义（均 P>0.05）。试验组试食后MDA水平显著低于试食前［（4.06±1.09）比（4.73±0.99）μmol/L］（ t=15.160， P<0.001），SOD水平显著高于试食前［（20 987±2 593）比（18 564±2 194）U/gHb］（ t=-4 338.337， P<0.05），GSH-Px水平差异无统计学意义（ P>0.05）。对照组试食前后MDA、SOD、GSH-Px水平差异均无统计学意义（均 P>0.05）。试食后试验组MDA水平显著低于对照组［（4.06±1.09）比（4.63±0.91）μmol/L］（ t=31.220， P<0.001），SOD水平显著高于对照组［（20 987±2 592.9）比（19 042±2 099.5）U/gHb］（ t=-3 124.231， P<0.05），GSH-Px水平差异无统计学意义（ P>0.05）。两组试食前后各项检测指标均处于正常范围；胸片、心电图及腹部B超检查均无异常改变；试食期间均未见过敏及不良反应，未见主观感觉和进食状况异常改变。 结论:海洋鱼低聚肽维生素C固体饮料能显著降低健康人群MDA水平，提高SOD水平，具有抗氧化功能，且安全性良好。

abstractsObjective:To evaluated the antioxidant function of marine fish oligopeptide vitamin C solid beverage in healthy people.Methods:From June 1st to December 31st, 2017, 110 volunteers aged 18 to 65 years in good health were recruited by Zhejiang Provincial Center for Disease Control and Prevention, and were randomly divided into control group and test group (55 cases in each group). The test group took the marine fish oligopeptide vitamin C solid beverage (the main components were marine fish oligopeptide powder, vitamin C, acai fruit powder, blueberry fruit powder, pomegranate fruit powder), and the control group took the placebo with the same appearance, package and taste as the solid beverage (the main components were maltodextrin, acai fruit powder, blueberry fruit powder, pomegranate fruit powder). The test samples were both packaged in 5 g/bag and were taken 1 bag daily for 4 months. During the trial, both groups maintained their daily life and dietary habits, and there were no other interventions except for the test samples. During the intervention, 3 cases dropped out, and finally, 53 cases were included in the control group and 54 cases in the test group. Before and after the test, the volunteers were examined for general physical conditions, routine blood, urine and stool tests, and biochemical indicators. At the same time, the levels of blood malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured, and the differences of various indicators between the two groups before and after the test were compared by t-test. Results:There was no significant difference in baseline data between the two groups (all P>0.05). After the test, the MDA level in the test group was significantly lower than that before the test [(4.06±1.09) vs (4.73±0.99) μmol/L] ( t=15.160, P<0.001), SOD level was significantly higher than that before the test [(20 987±2 593) vs (18 564±2 194) U/gHb] ( t=-4 338.337, P<0.05), there was no significant change in GSH-Px level before and after the test ( P>0.05). There was no significant differences in the levels of MDA, SOD and GSH-Px in the control group before and after the test (all P>0.05). After trial feeding, the MDA level in the test group was significantly lower than that in the control group [(4.06±1.09) vs (4.63±0.91)] μmol/L] ( t=31.220, P<0.001), SOD level was higher than that in the control group [(20 987±2 593) vs (19 042±2 100) U/gHb] ( t=-3 124.231, P<0.05), there was no significant difference in GSH-Px level between the two groups ( P>0.05). All the test indexes in the two groups were in the normal range before and after the test; there were no abnormal changes in chest radiography, electrocardiogram and abdominal B-ultrasonography; during the trial feeding, no allergy or adverse reaction was found, and no abnormal change of subjective feeling and eating condition was found. Conclusion:Marine fish oligopeptide vitamin C solid beverage can significantly reduce the level of MDA, improve the level of SOD, it has antioxidant function and good safety.