摘要目的:分析中老年健康体检人群高尿酸血症（HUA）检出率及血尿酸水平分布的多重对应关系。方法:本研究为横断面研究。选取南方医院2014年1至12月的25 587例中老年健康体检者为研究对象。按照最新的诊断标准将人群分为HUA和非HUA两组，并按照血尿酸水平分为4个组（Q 1：血尿酸<313 μmol/L，Q 2：313 μmol/L≤血尿酸<375 μmol/L，Q 3：375 μmol/L≤血尿酸<440 μmol/L，Q 4：血尿酸≥440 μmol/L）。根据数据类型，分别使用两独立样本 t检验、Mann-Whitney U检验、卡方检验及多重对应分析进行统计分析。 结果:研究对象年龄为（54.78±8.80）岁，其中男性16 570例（64.8%），女性9 017例（35.2%）。总体上HUA检出率为31.5%，男性检出率（43.1%）高于女性（10.1%）。HUA组体重指数、舒张压、收缩压、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、空腹血糖等指标均高于非HUA组（均 P<0.001）；高密度脂蛋白胆固醇低于非HUA组（ P<0.001）。多重对应分析中，第一维度和第二维度的Cronbach′s α系数分别为0.608、0.237。进一步按性别分层分析，男性45~<55岁、超重与血尿酸Q 3组关联密切，脂肪肝、高血脂与血尿酸Q 4组关联密切；中老年女性55~<65岁、高血脂、脂肪肝、肥胖与血尿酸Q 3组关联密切，高血糖、高血压与血尿酸Q 4组关联密切。 结论:中老年体检人群HUA检出率较高，男性高于女性。中老年男性中脂肪肝和高血脂者的血尿酸水平更高，中老年女性中高血糖和高血压者的血尿酸水平更高。

abstractsObjective:To analyze the detection rate of hyperuricemia (HUA) and the distribution of serum uric acid (SUA) levels by multiple correlation analysis in middle-aged and elderly population receiving health examination.Methods:In this cross-sectional study, the study object were 25 587 middle-aged and elderly people who receiving health examination in Nanfang Hospital from January to December in 2014. According to the latest diagnostic criteria, the population was divided into HUA and non-HUA groups. Furthermore, the subjects were divided into 4 groups with the level of SUA (Q 1: SUA<313 μmol/L, Q 2:313 μmol/L≤SUA<375 μmol/L, Q 3:375 μmol/L≤SUA<440 μmol/L, Q 4: SUA≥440 μmol/L). According to the data types, two independent sample t test, Mann-Whitney U test, Chi-square test and multiple correspondence analysis were used for statistical analysis. Results:The mean age of the study subjects was (54.78±8.80) years with 16 570 males (64.8%) and 9 017 females (35.2%). The overall detection rate of HUA was 31.5%, and it was higher in men (43.1%) than in women (10.1%). The body mass index(BMI), systolic blood pressure, diastolic blood pressure, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and fasting blood glucose (FBG) in the HUA group were all higher than those in the non-HUA group (all P<0.001); and high-density lipoprotein cholesterol (HDL-C) was lower than that in the non-HUA group( P<0.001). In multiple correspondence analysis, Cronbach′s α coefficients of the first dimension and the second dimension was 0.608 and 0.237, respectively. Further analysis was performed stratified by gender, it indicated that 45-<55 years old male and overweight were closely associated with the Q 3 group, fatty liver and hyperlipidemia were closely associated with Q 4 group; the 55-<65 years old female, hyperlipidemia, fatty liver and obesity were closely associated with the Q 3 group, while hyperglycemia and hypertension were closely associated with the Q 4 group. Conclusion:The detection rate of HUA in middle-aged and elderly population receiving health examination was high, and the detection rate of HUA in male was higher than that in female. SUA levels are higher in middle-aged and elderly men who have fatty liver and hyperlipidemia. While SUA levels are higher in middle-aged and elderly women who have hyperglycemia and hypertension.