摘要近10年，全球在抑郁症研究领域取得了稳健进展。流行病学研究显示，抑郁症呈现高患病率、年轻化和职业化趋势以及负担重等现状。在病因学方面，通过全基因组关联研究阐明了抑郁症的遗传度，通过影像学研究区分了抑郁症不同生物亚型，通过多组学研究探讨了抑郁症潜在生物标志物。在临床治疗学方面，新型治疗药物的研发和神经调控技术的应用，为抑郁症治疗提供了新策略；数字疗法的兴起，为患者提供了个性化的全病程管理。本文中总结了近10年抑郁症在流行病学、病因学和临床治疗学方面的主要研究进展和热点问题，旨在促进临床医生对抑郁症研究现状和前景的了解。

abstractsOver the past decade, the research on major depressive disorder (MDD) has made steady progress globally. The prevalence of MDD is high with a noticeable trend toward younger and professional. Additionally, MDD is grappling with heavy burdens. Genome-wide association studies have shed light on the heritability of MDD, while imaging studies have identified diverse biological subtypes. Furthermore, multi-omics studies have uncovered potential biomarkers for the condition. The emergence of novel therapeutic agents and advancements in brain stimulation techniques have introduced innovative strategies for the management of MDD. Digital therapeutics are rapidly advancing, holding the promise of delivering personalized and full-course care for MDD patients. This article provides a comprehensive overview of the key research progress and hot spots in the epidemiology, etiology, and clinical therapeutics of MDD over the past decade. It aims to assist clinicians in understanding the current state of research and the future directions within this domain.