摘要目的 探讨肠球菌属的分布特征及耐药性变迁,为临床治疗提供参考.方法 回顾性分析2001至2007年湖州市中心医院和湖州市第一人民医院各类临床标本中分离出的肠球菌属的分布特点、检出率及药物敏感性.结果 94876份临床标本中检出肠球菌2547株(2.68%),其中粪肠球菌为主要菌种,屎肠球菌次之.肠球菌属在各种临床标本中的分布仍以尿液为主,痰液标本中肠球菌属的比例逐年增加.肠球菌属对红霉素、利福平、环丙沙星和左氧氟沙星具有较高的耐药性.粪肠球菌对青霉素、氨苄西林和呋喃妥因敏感性较好;屎肠球菌的耐药率逐年上升,但对四环素和氯霉素的耐药率低于粪肠球菌.肠球菌属对万古霉素和替考拉宁仍然保持很高的敏感性.结论 肠球菌属感染以粪肠球菌和屎肠球菌为主,由其引起的呼吸道感染在增加.肠球菌届的总体耐药率较高,临床上应根据药物敏感性试验结果选择敏感的抗菌药物治疗.

abstractsObjective To investigate the characteristics of distribution and the changes in drug resistance of Enterococci,providing reference for clinical treatment.Methods The distribution and drug resistance in 2547 clinical isolates of Enterococci from 2001 to 2007 in Huzhou Central Hospital and the First People's Hospital of Huzhou were retrospectively analyzed.Results A total of 2547 strains of Enterococci were isolated from 94876 clinical specimens(2.68%),in which Enterococcus faecalis wag primary and Enterococcus faecium Wag ranking the second.The positive rate of Enterococci in urine specimens was the highest,and that in sputum specimens was increasing recently.Enterococci showed higg resistance to erythromycin,rifampin,ciprofloxacin and levofloxacin;Enterococcus faecalis Wag more sensitive to penicillin,ampiciilin and ndtrofurantoin than Enterococcus faecium,while Euterococcus faecium was more sensitive to chloramphended and tetracycline than Enterococcus faecalis;both of them were sensitive to vaneomycin and teicoplanin.Conclusions Enterococcus faecalis and Enterococcus faecium are the common pathogen in Enterococci infections.Enterococci show high drug resistance,so the clinical use of antibiotics should be based on the resuhs of drug sensitivity test.