摘要目的 探讨非霍奇金淋巴瘤(NHL)患者医院感染的危险因素和预防措施.方法 回顾性调查分析2007年1-12月65例NHL患者医院感染的易感因素.结果 58例患者的NHL属于B细胞,7例属于T细胞.所有患者均接受CHOP方案作为初始化疗,23例发生医院感染.医院感染发生率与年龄、住院天数、病理类型、骨髓侵犯、乳酸脱氢酶、β2微球蛋白及侵袭性治疗等因素有关.感染部位以呼吸道为主,感染菌以革兰阴性杆菌为主.结论 NHL患者易发生医院感染,控制易感因素是预防医院感染的有效方法.

abstractsObjective To identify risk factors and preventive measures of nosoconial infections in patients with non-Hodgkin lymphoma (NHL). Methods Clinical data of 65 NHL patients admitted from January to December 2007 were retrospectively analyzed. Results According to WHO classification (2001), 58 patients were with B-cell lymphoma, 7 were with T-cell lymphorna. All patients received CHOP regimen as initial chemotherapy and 23 of them were with nosecomial infections. Logistic regression analysis demonstrated that age, length of stay, pathological type, bone marrow involvement, levels of serum lactate dehydrogenase (LDH), beta2-microglobulin and invasive treatment were identified as risk factors of nosocomial infections. Respiratory tract infections and infections with gram-negative microorganisms were the most popular. Conclusion High nosocomial infection rate is found in NHL patients, and control of risk factors may effectively prevent nosocomial infections in NHL patients.